The goal of the "Ground-Based Venous Thromboembolism (VTE) Pathophysiology and Analog Solicitation" is to advance our understanding of VTE pathophysiology in the context of spaceflight-associated hemodynamic changes and to develop and validate ground-based analogs that replicate these conditions. Proposals should address one of the following areas:
(1) Pathophysiology studies that advance mechanistic understanding of thrombus formation under conditions of retrograde venous flow, stasis, or vessel distention relevant to spaceflight; or/and
(2) Development and validation of ground-based analogs and model, including in-silico, in-vitro, ex-vivo, in-vivo, human-subject, and hybrid approaches, that reliably reproduce key in-space hemodynamic conditions and enable investigation of venous thrombus formation and progression.
Deliverables should be appropriate to the proposed area(s) of focus. Pathophysiology proposals should deliver mechanistic characterization data and analyses. Analog proposals should deliver a validated analog protocol, population variability datasets, and characterization reports.
Award Information
Proposals can request up to $500K in total costs (direct + indirect costs) over a performance period of up to 15 months. Awards can begin as early as January 2027 and must be initiated by March 2027. Projects must conclude by March 31, 2028. Selected proposals will be funded as research grants.
Eligibility
All categories of United States (U.S.) institutions and companies are eligible to submit proposals. Principal Investigators (PIs) may collaborate with universities, the private sector, and federal, state, and local government laboratories. In all such arrangements, the applying entity is expected to be responsible for administering the project according to the management approach presented in the proposal. For our policy on international proposers and institutions, please refer to the FAQ and FAR Supplement.
Please see the solicitation documents below for detailed information:
Frequently Asked Questions (FAQ)
Ground-Based Venous Thromboembolism (VTE) Pathophysiology and Analog Solicitation
The goal of the "Ground-Based Venous Thromboembolism (VTE) Pathophysiology and Analog Solicitation" is to advance our understanding of VTE pathophysiology in the context of spaceflight-associated hemodynamic changes and to develop and validate ground-based analogs that replicate these conditions. Proposals should address one of the following areas:
(1) Pathophysiology studies that advance mechanistic understanding of thrombus formation under conditions of retrograde venous flow, stasis, or vessel distention relevant to spaceflight; or/and
(2) Development and validation of ground-based analogs and model, including in-silico, in-vitro, ex-vivo, in-vivo, human-subject, and hybrid approaches, that reliably reproduce key in-space hemodynamic conditions and enable investigation of venous thrombus formation and progression.
Deliverables should be appropriate to the proposed area(s) of focus. Pathophysiology proposals should deliver mechanistic characterization data and analyses. Analog proposals should deliver a validated analog protocol, population variability datasets, and characterization reports.
Award Information
Proposals can request up to $500K in total costs (direct + indirect costs) over a performance period of up to 15 months. Awards can begin as early as January 2027 and must be initiated by March 2027. Projects must conclude by March 31, 2028. Selected proposals will be funded as research grants.
Eligibility
All categories of United States (U.S.) institutions and companies are eligible to submit proposals. Principal Investigators (PIs) may collaborate with universities, the private sector, and federal, state, and local government laboratories. In all such arrangements, the applying entity is expected to be responsible for administering the project according to the management approach presented in the proposal. For our policy on international proposers and institutions, please refer to the FAQ and FAR Supplement.
Please see the solicitation documents below for detailed information:
Frequently Asked Questions (FAQ)